SELECTED PUBLICATIONS IN PEER REVIEWED JOURNALS
SELECTED PUBLICATIONS IN PEER REVIEWED JOURNALS
Martins-Marques T, Costa MC, Catarino S, Simoes I, Aasen T, Enguita FJ, Girao H. Cx43-mediated sorting of miRNAs into extracellular vesicles. EMBO reports 2022 May 20:e54312 (Impact Factor: 8.8; Q1)
Alves-Silva JM, Zuzarte M, Marques C, Viana S, Preguiça I, Baptista R, Ferreira C, Cavaleiro C, Domingues N, Sardão VA, Oliveira PJ, Reis F, Salgueiro L, Girão H. 1,8-Cineole ameliorates right ventricle dysfunction associated with pulmonary arterial hypertension by restoring connexin43 and mitochondrial homeostasis. Pharmacol Res. 2022 Jun;180:106151 (Impact Factor: 7.658; Q1)
Martins-Marques T, Girão H. The good, the bad and the ugly: the impact of extracellular vesicles on the cardiovascular system. J Physiol. 2022 Mar 29 (Impact Factor: 5.182; Q1)
Domingues N, Gonçalves T, Girao H. Phagolysosomal remodeling to confine Candida albicans in the macrophage. Trends Microbiol. 2022 Jun;30(6):519-523 (Impact Factor: 17.079; Q1)
Pesce M, Agostoni P, Bøtker HE, Brundel B, Davidson SM, De Caterina R, Ferdinandy P, Girao H, Gyöngyösi M, Hulot JS, Lecour S, Perrino C, Schulz R, Sluijter JPG, Steffens S, Tancevski I, Gollmann-Tepeköylü C, Tschöpe C, van Linthout S, Madonna R. COVID-19 related cardiac complications - from clinical evidences to basic mechanisms. Opinion paper of the ESC Working Group on Cellular Biology of the Heart. Cardiovasc Res. 2021 Jun 12:cvab201 (Impact Factor: 10.787; Q1)
Alves-Silva JM, Zuzarte M, Girão H, Salgueiro L. The Role of Essential Oils and Their Main Compounds in the Management of Cardiovascular Disease Risk Factors. Molecules. 2021 Jun 9;26(12):3506 (Impact Factor: 4.411; Q2)
Martins-Marques T, Rodriguez-Sinovas A, Girao H. Cellular crosstalk in cardioprotection: Where and when do reactive oxygen species play a role? Free Radic Biol Med. 2021 Jun;169:397-409 (Impact Factor: 7.376; Q1)
Klionsky DJ, (…), Girao H, (…), Tong C. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Feb;1-382 (Impact Factor: 16.016; Q1)
Martins-Marques T, Ribeiro-Rodrigues T, de Jager SC, Zuzarte M, Ferreira C, Cruz P, Reis L, Baptista R, Gonçalves L, Sluijter JP, Girao H. Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes. Life Sci Alliance. 2020;3(12):e202000821 (Impact Factor: 4.591; Q1)
Martins-Marques T, Hausenloy DJ, Sluijter JPG, Leybaert L, Girao H. Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia. Trends Mol Med. 2020 Oct 30:S1471-4914(20)30263-X (Impact Factor: 11.099; Q1)
Tishchenko A, Azor.n DD, Vidal-Brime L, Mu.oz MJ, Arenas PJ, Pearce C, Girao H, Ramon Y Cajal S, Aasen T. Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells. Cancers (Basel). 2020 Sep 29;12(10):2798 (Impact Factor: 6.126; Q1)
Santos-Ferreira CA, Abreu MT, Marques CI, Gonçalves LM, Baptista R, Girão HM. Micro-RNA Analysis in Pulmonary Arterial Hypertension: Current Knowledge and Challenges. JACC Basic Transl Sci. 2020 Nov 23;5(11):1149-1162
Rusiecka OM, Montgomery J, Morel S, Batista-Almeida D, Van Campenhout R, Vinken M, Girao H, Kwak BR. Canonical and Non-Canonical Roles of Connexin43 in Cardioprotection. Biomolecules. 2020 Aug 23;10(9):1225 (Impact Factor: 4.082; Q2)
Batista-Almeida D, Ribeiro-Rodrigues T, Martins-Marques T, Cortes L, Antunes PE, Gonçalves L, Brou C, Aasen T, Zurzolo C, Girão H. Ischaemia impacts TNT-mediated communication between cardiac cells. Curr Res Cell Biol. 2020;1:100001.
Aires ID, Ribeiro-Rodrigues T, Boia R, Catarino S, Girão H, Ambrosio AF, Santiago AR. Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells. Glia. 2020 Dec;68(12):2705-2724 (Impact Factor: 5.984; Q1)
Gaspar LS, Santana MM, Henriques C, Pinto MM, Ribeiro-Rodrigues TM, Girão H, Nobre RJ, Pereira de Almeida L. Simple and Fast SEC-Based Protocol to Isolate Human Plasma- Derived Extracellular Vesicles for Transcriptional Research. Mol Ther Methods Clin Dev. 2020 Jul 15;18:723-737 (Impact Factor: 4.533; Q1)
Perrino C, Ferdinandy P, (…) Girao H, (…), Ytrehus K. Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart. Cardiovasc Res. 2020 Jun (Impact Factor: 8.168; Q1)
Hernandez-Resendiz S, Prunier F, Girao H, Dorn G, Hausenloy DJ; EUCARDIOPROTECTION COST Action (CA16225). Targeting mitochondrial fusion and fission proteins for cardioprotection. J Cell Mol Med. 2020 Jun;24(12):6571-6585 (Impact Factor: 4.486; Q2)
Hausenloy DJ, Schulz R, Girao H, Kwak BR, De Stefani D, Rizzuto R, Bernardi P, Di Lisa F. Mitochondrial ion channels as targets for cardioprotection. J Cell Mol Med. 2020 Jul;24(13):7102-7114 (Impact Factor: 4.486; Q2)
Martins-Marques T, Catarino S, Gonçalves A, Miranda-Silva D, Gonçalves L, Antunes P, Coutinho G, Leite Moreira A, Falcao Pires I, Girão H. EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac Diseases. Circ Res. 2020 May 8;126(10):e97-e113 (Impact Factor: 14.467; Q1)
Catarino S, Ribeiro-Rodrigues TM, S. Ferreira R, Ramalho J, Abert C, Martens S, Girão H. A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins. Cells. 2020 Apr 7;9(4):902 (Impact Factor: 4.366; Q2)
Martins-Marques T, Ribeiro-Rodrigues T, Batista-Almeida D, Aasen T, Kwak BR, Girao H. Biological Functions of Connexin43 Beyond Intercellular Communication. Trends Cell Biol. 2019 Oct;29(10):835-847 (Impact Factor: 16.041; Q1)
Ferreira JV, Rosa Soares A, Ramalho JS, Ribeiro-Rodrigues T, Maximo C, Zuzarte M, Girão H, Pereira P. Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis. PLoS One. 2019 Oct 15;14(10):e0223790 (Impact Factor: 2.740; Q2)
Lissoni A, Hulpiau P, Martins-Marques T, Wang N, Bultynck G, Schulz R, Witschas K, Girao H, De Smet M, Leybaert L. RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes. Cardiovasc Res. 2019 Dec 16;117(1):123-136 (Impact Factor: 8.168; Q1)
Dissmeyer N, Coux O, Rodriguez MS, (…) Girao H, (…) Barrio R; Core Group Members of PROTEOSTASIS. PROTEOSTASIS: A European Network to Break Barriers and Integrate Science on Protein Homeostasis. Trends Biochem Sci. 2019 May;44(5):383-387 (Impact Factor: 14.732; Q1)
Davidson SM, Andreadou I, Barile L, Birnbaum Y, Cabrera-Fuentes HA, Cohen MV, Downey JM, Girao H, Pagliaro P, Penna C, Pernow J, Preissner KT, Ferdinandy P. Circulating blood cells and extracellular vesicles in acute cardioprotection. Cardiovasc Res. 2019 Jun 1;115(7):1156-1166 (Impact Factor: 8.168; Q1)
Almeida Paiva R, Martins-Marques T, Jesus K, Ribeiro-Rodrigues T, Zuzarte M, Silva A, Reis L, da Silva M, Pereira P, Vader P, Petrus Gerardus Sluijter J, Gon.alves L, Cruz MT, Girao H. Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation. J Cell Mol Med. 2019 Feb;23(2):1137-1151 (Impact Factor: 4.486; Q2)
Andreadou I, Adamovski P, (…) Girão H, (…) Ferdinandy P , Hausenloy DJ Realizing the therapeutic potential of novel cardioprotective therapies: The EU-CARDIOPROTECTION COST Action–CA16225. Conditioning Medicine 2018, 1:116-123.
Delgado-Silva J, Fernandes R, Pita IR, Pereira FC, Jaguszewski M, Gutierrez-Chico JL, Ribeiro-Rodrigues T, Girão H, Ioannou A, Gonçalves L. Intravascular imaging, histopathological analysis, and catecholamine quantification following catheter-based renal denervation in a swine model: the impact of prebifurcation energy delivery. Hypertens Res. 2018 Sep;41(9):708-717 (Impact Factor: 3.217; Q2)
Pereira O, Teixeira A, Sampaio-Marques B, Castro I, Girão H, Ludovico P. Signalling mechanisms that regulate metabolic profile and autophagy of acute myeloid leukaemia cells. J Cell Mol Med. 2018 Oct;22(10):4807-4817 (Impact Factor: 4.658; Q1)
Baptista R, Marques C, Catarino S, Enguita FJ, Costa MC, Matafome P, Zuzarte M, Castro G, Reis A, Monteiro P, P.go M, Pereira P, Girão H. MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1. Cardiovasc Res. 2018 Jan 1;114(1):53-64 (Impact Factor: 7.014; Q1)
Catarino S, Pereira P, Girão H. Molecular control of chaperone-mediated autophagy. Essays Biochem. 2017 Dec 12;61(6):663-674 (Impact Factor: 3.338; Q1)
Ribeiro-Rodrigues TM, Martins-Marques T, Morel S, Kwak BR, Girão H. Role of connexin43 in different forms of intercellular communication - gap junctions, extracellular vesicles and tunnelling nanotubes. J Cell Sci. 2017 Nov 1;130(21):3619-3630 (Impact Factor: 4.401; Q2)
Ribeiro-Rodrigues TM, Laundos TL, Pereira-Carvalho R, Batista-Almeida D, Pereira R, Coelho-Santos V, Silva AP, Fernandes R, Zuzarte M, Enguita FJ, Costa MC, Pinto-do-. P, Pinto MT, Gouveia P, Ferreira L, Mason JC, Pereira P, Kwak BR, Nascimento DS, Girão H. Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis. Cardiovasc Res. 2017 Sep 1;113(11):1338-1350 (Impact Factor: 6.290; Q1)
Deddens JC, Vrijsen KR, Girao H, Doevendans PA, Sluijter JP. Cardiac-released extracellular vesicles can activate endothelial cells. Ann Transl Med. 2017 Feb;5(3):64 (Impact Factor: 3.689; Q2)
Melo T, Domingues P, Ribeiro-Rodrigues TM, Girão H, Segundo MA, Domingues MRM. Characterization of phospholipid nitroxidation by LC-MS in biomimetic models and in H9c2 Myoblast using a lipidomic approach. Free Radic Biol Med. 2017 May;106:219-227 (Impact Factor: 6.020; Q1)
Martins-Marques T, Pinho MJ, Zuzarte M, Oliveira C, Pereira P, Sluijter JP, Gomes C, Girao H. Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin. J Extracell Vesicles. 2016 Sep 29;5:32538 (Impact Factor: 11.000; Q1)
Da Silva-Ferrada E, Ribeiro-Rodrigues TM, Rodr.guez MS, Girão H. Proteostasis and SUMO in the heart. Int J Biochem Cell Biol. 2016 Oct;79:443-450 (Impact Factor: 3.505; Q2)
Alves-Silva JM, Zuzarte M, Marques C, Salgueiro L, Girao H. Protective Effects of Terpenes on the Cardiovascular System: Current Advances and Future Perspectives. Curr Med Chem. 2016;23:4559-4600 (Impact Factor: 3.249; Q2)
Martins-Marques T, Isabel Anjo S, Pereira P, Manadas B, Girão H. Interacting network of the gap junction (GJ) protein connexin43 (Cx43) is modulated by ischemia and reperfusion in the heart. Mol Cell Proteomics. 2015 Nov;14(11):3040-55 (Impact Factor: 5.912; Q1)
Soares AR, Martins-Marques T, Ribeiro-Rodrigues T, Ferreira JV Catarino S, Pinho MJ, Zuzarte M, Anjo SI, Manadas B, Sluijter JPG, Pereira P, Girão H. Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells. Sci Rep. 2015 Aug 19;5:13243 (Impact Factor: 5.228; Q1)
Santos-Oliveira P, Correia A, Rodrigues T, Ribeiro-Rodrigues T, Matafome P, Rodriguez-Manzaneque JC, Seica R, Girão H, Travasso RDM. The force at the tip - modelling tension and proliferation in sprouting angiogenesis. PLoS Comput Biol. 2015 Aug 6;11(8):e1004436 (Impact Factor: 4.587; Q1)
Ribeiro-Rodrigues T, Catarino S, Pinho MJ, Pereira P and Girão H. Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive. Biochem Soc Trans. 2015 Jun;43(3):471-5 (Impact Factor: 2.679; Q2)
Martins-Marques T, Catarino S, Marques C, Pereira P, Girão H. To beat or not to beat: degradation of Cx43 imposes the heart rhythm. Biochem Soc Trans. 2015 Jun;43(3):476-81 (Impact Factor: 2.679; Q2)
Ferreira JV, Soares A, Ramalho JS, Pereira P, Girão H. K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy. Sci Rep. 2015 May 11;5:10210 (Impact Factor: 5.228; Q1)
Martins-Marques T, Catarino S, Marques C, Matafome P, Ribeiro-Rodrigues T, Pereira P, Girão H. Heart ischemia results in Connexin43 ubiquitination localized at the intercalated discs. Biochimie. 2015 May;112:196-201 (Impact Factor: 3.017; Q2)
Martins-Marques T, Catarino S, Zuzarte M, Marques C, Matafome P, Pereira P, Girão H. Ischemia-induced autophagy leads to degradation of gap junction protein Connexin43 in cardiomyocytes. Biochem J. 2015 Apr 15;467(2):231-45 (Impact factor: 3.562; Q2)
Martins-Marques T, Ribeiro-Rodrigues T, Pereira P, Codogno P, Girão H. Autophagy and Ubiquitination in Cardiovascular Diseases. DNA Cell Biol. 2015 Apr;34(4):243-51 (Impact Factor: 2.574; Q2)
Santos-Almeida FM, Girão H, Silva CA, Salgado HC Becari, Fazan R Jr. Cholinergic stimulation with pyridostigmine protects myocardial infarcted rats against ischemic-induced arrhythmias and preserves connexin 43 protein. Am J Physiol Heart Circ Physiol. 2015 Jan 15;308(2):H101-7 (Impact Factor: 3.324; Q2)
Ribeiro-Rodrigues T, Catarino S, Marques C, Ferreira J, Marques T, Pereira P, Girão H. AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions. FASEB J. 2014 Nov;28(11):4629-41 (Impact Factor: 5.043; Q1)
Ferreira JV, Fofo H, Bejarano E, Figueira Bento C, Ramalho JS, Girão H, Pereira P. CHIP/STUB1 is required for HIF-1A degradation by Chaperone-Mediated Autophagy. Autophagy. 2013 Sep;9(9):1349-66 (Impact Factor: 11.423; Q1)
Bejarano E*, Girão H*, Yuste A, Patel B, Marques C, Spray D, Cuervo AM, Pereira P. Autophagy modulates dynamics of connexins at the plasma membrane in an ubiquitin-dependent manner. Mol Biol Cell. 2012 Jun;23(11):2156-69 (Impact Factor: 4.803; Q1)
Catarino S, Ramalho JS, Marques C, Pereira PC, Girão H. Ubiquitin-mediated internalization of Connexin43 is independent on the canonical endocytic tyrosine-sorting signal. Biochem J. 2011 Jul 15;437(2):255-67 (Impact Factor: 4.897; Q1)